Hypertension

Cardiovascular diseases are a leading cause of mortality and morbidity worldwide, and hypertension remains one of the most important risk factors for them.

The elevated blood pressure in systemic arterial hypertension is associated with a decline in endothelium-dependent vasodilation, resulting in an overall increase in vascular tone and resistance, the hallmark of the disease.

Preclinical services offered

  • Drug screening in in vivo (rat, mouse) and ex vivo models
  • Evaluation of compounds effects on blood pressure, vascular resistance, endothelial and smooth muscle cells function

Experimental platform

Hypertension model

Gold standard models of hypertension

Combined disease models: Hypertension with risk factors and co-morbidities such as hyperlipidemia, obesity and diabetes

Specific expertise in flow-induced dilation and pressure-induced constriction

View our factsheet by clicking on the document on the right.

In vivo models

  • Genetic animal models
    РSpontaneous Hypertensive  rat model (SHR)
    – Dahl Salt sensitive rat
    – BPH/Slg mouse (Blood Pressure High)
  • Non genetic models (rat and mouse)
    – DOCA-salt
    – High-Salt diet
    – Other models on request

Techniques available

We propose a wide range of techniques to deliver key end-points: Telemetry, Tail cuff, Isometric wire myography, Pressure myography (this physiological approach allows pressurization of small arteries such that they assume the conformational structure they would achieve in vivo) and Histology.

All of our studies are designed following our clients’ requests, please contact us for more information.


 
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