Septic / Hemorrhagic shock
Typical sign of shock are sustained hypotension (systolic blood pressure (BP) <90 mm Hg for more than 30 minutes), decreased oxygen delivery, decreased tissue perfusion, and cellular hypoxia.
Such alterations lay the foundations for subsequent development of mutlti-organ failure, a systemic inflammatory process that leads to dysfunction of different vital organs and accounts for high mortality rates. Depending of the causes, several types of shock can occur.
Preclinical services offered
- Drug screening in in vivo (rat, mouse) and ex vivo models
- Evaluation of compounds effects on cardiovascular parameters
Cardiomedex focuses particularly on:
- Hypovolemic shock, the single most common cause of shock, due to blood volume loss.
- Septic shock caused by overwhelming infection leading to vasodilation.
View our factsheet by clicking on the document on the right.
In vivo models
- Septic shock models
– Cecal ligation and puncture (CLP) –induced septicemia (rat, mouse)
– LPS-induced sepsis (rat, mouse)
- Hemorrhagic shock model (rat, mouse)
We propose a wide range of techniques to deliver key end-points: Electrocardiography, Millar probes, Arterial catheterization, Telemetry, Isolated aortic/carotid rings and Biochemistry.
All of our studies are designed following our clients’ requests, please contact us for more information.