Septic / Hemorrhagic shock

Typical sign of shock are sustained hypotension (systolic blood pressure (BP) <90 mm Hg for more than 30 minutes), decreased oxygen delivery, decreased tissue perfusion, and cellular hypoxia.

Such alterations lay the foundations for subsequent development of mutlti-organ failure, a systemic inflammatory process that leads to dysfunction of different vital organs and accounts for high mortality rates. Depending of the causes, several types of shock can occur.

Preclinical services offered

  • Drug screening in in vivo (rat, mouse) and ex vivo models
  • Evaluation of compounds effects on cardiovascular parameters

Cardiomedex focuses particularly on:

  • Hypovolemic shock, the single most common cause of shock, due to blood volume loss.
  • Septic shock caused by overwhelming infection leading to vasodilation.

Experimental platform

Septic hemorrhagic shock

Gold standard models for the study of the systemic inflammatory response syndrome (SIRS).

View our factsheet by clicking on the document on the right.

In vivo models

  • Septic shock models
    – Cecal ligation and puncture (CLP) –induced septicemia (rat, mouse)
    – LPS-induced sepsis (rat, mouse)
  • Hemorrhagic shock model (rat, mouse)

Techniques available

We propose a wide range of techniques to deliver key end-points: Electrocardiography, Millar probes, Arterial catheterization, Telemetry, Isolated aortic/carotid  rings and Biochemistry.

All of our studies are designed following our clients’ requests, please contact us for more information.


 
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