Heart failure

Heart failure, also known as congestive heart failure (CHF) has become a leading cause of death in the industrialized world. It is now recognized that a major element of heart failure results from the maladaptive remodeling of the heart that occurs after hemodynamic loads.

Common causes of heart failure include myocardial infarction and other forms of ischemic heart disease, coronary artery disease, hypertension, valvular heart disease, and cardiomyopathy.

Preclinical services offered

  • Drug screening in in vivo (rat, mouse), in vitro and ex vivo models
  • Evaluation of compounds effects on ventricular remodeling and dysfunction

Experimental platform

Heart failure model

Gold standard models to evaluate development of ventricular dysfunction and transition to overt heart failure. View our factsheet by clicking on the document on the right.

In vivo models

  • Myocardial infarction (rat, mouse): left coronary ligation
  • Thoracic aortic banding (rat, mouse)
  • Anthracycline-induced congestive heart failure

Ex vivo / vitro assays

  • Langendorff heart model
  • Isolated cardiomyocytes

Techniques available

We propose a wide range of techniques to deliver key end-points: Echocardiography, Electrocardiogram, Millar probes, Telemetry, Histomorphology, Anatomopathology, Myocyte Calcium and Contractility Recording System, Biochemistry and Molecular Biology.

All of our studies are designed following our clients’ requests, please contact us for more information.


See also:

 

 
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