In vivo technical platform
In vivo assays for cardiac function and hemodynamic parameters assessment
Our services include invasive and non invasive studies, cardiovascular parameters measurement in anesthetized or conscious free moving animals (rats, mice), and access to specialized animal models to achieve drug screening, efficacy test and evaluation of cardio-protective effects.
- In-depth scientific and disease-related knowledge
- Tailor-made projects
- Scientific consulting
- Telemetry monitoring
Cardiomedex offers surgical implantation of miniature device to measure one or more parameters (e.g., blood pressure, heart rate, ECG, temperature, etc.).
Using implanted telemetry monitors allows measurements free from the effects of anesthesia in conscious freely moving animals.
- Non-invasive assays in rodents
Echocardiography is very usefull to assess myocardial contractility and heart function, abnormalities of left ventricular chamber, wall motion and thickness in rodent and surgical rodent models of heart diseases.
Surface electrocardiogram is used to measure electrical activity of the heart to highlight cardiac arrhythmias in anesthetized animals submitted to drug infusion or in surgical models.
Tail cuff acquisition system consists in intermittently measurement of blood pressure based on the periodic occlusion of tail blood flow in concious animals.
- Left Ventricular Pressure/Volume loops analysis
Real time left ventricular (LV) pressure-volume loops provide a framework for understanding cardiac mechanics. The system enables the measurement of load independent in addition to variable loading parameters of cardiac function such as stroke volume, cardiac output, ejection fraction, myocardial contractility, etc.
- Heart rate variability analysis
Heart rate variability (HRV) is considered as one of the most promising quantitative markers of autonomic activity. As reduction of HRV has been reported in several cardiological and non-cardiological diseases, the HRV analysis is a powerful tool to provide valuable insight into physiological and pathological conditions and also enhance risk stratification.