Key Publications


  • Dague E, Genet G, Lachaize V, Guilbeau-Frugier C, Fauconnier J, Mias C, Payré B, Chopinet L, Alsteens D, Kasas S, Severac C, Thireau J, Heymes C, Honton B, Lacampagne A, Pathak A, Sénard JM, Galés C.
    Atomic force and electron microscopic-based study of sarcolemmal surface of living cardiomyocytes unveils unexpected mitochondrial shift in heart failure.
    J Mol Cell Cardiol. 2014 May 17.  [Epub ahead of print]
  • Tanguy S, Toufektsian MC, Grauzam S, de Leiris J, Ghezzi C, Boucher F, Sulpice T.
    Cardiac dysfunction in rats with dietary-induced insulin resistance associated with pharmacologically-induced dyslipidemia.
    Curr Pharm Des. 2013;19(39):6906-11.
  • Saulière A, Bellot M, Paris H, Denis C, Finana F, Hansen JT, Altié MF, Seguelas MH, Pathak A, Hansen JL, Sénard JM, Galés C.
    Deciphering biased-agonism  complexity reveals a new active AT1 receptor entity.
    Nat Chem Biol. 2012, Jul;8(7):622-30.
  • Genet G, Guilbeau-Frugier C, Honton B, Dague E, Schneider MD, Coatrieux C,Calise D, Cardin C, Nieto C, Payré B, Dubroca C, Marck P, Heymes C, Dubrac A, Arvanitis D, Despas F, Altié MF, Seguelas MH, Delisle MB, Davy A, Sénard JM, Pathak A, Galés C.
    Ephrin-B1 is a novel specific component of the lateral membrane of the cardiomyocyte and is essential for the stability of cardiac tissue architecture cohesion.
    Circ Res. 2012, Mar 2;110(5):688-700.
  • Denis C, Saulière A, Galandrin S, Sénard JM and Galés C.
    Probing Heterotrimeric G Protein Activation: Applications to Biased Ligands.
    Curr Pharm Des. 2012;18(2):128-44.
  • Flamant M, Placier S, Dubroca C, Esposito B, Lopes I, Chatziantoniou C, Tedgui A, Dussaule JC, Lehoux S.
    Role of matrix metalloproteinases in early hypertensive vascular remodeling.
    Hypertension. 2007 Jul;50(1):212-8.
  • Harmancey R, Senard JM, Rouet P, Pathak A, Smih F.
    Adrenomedullin inhibits adipogenesis under transcriptional control of insulin.
    Diabetes. 2007 Mar;56(3):553-63.
  • Roncalli J, Smih F, Desmoulin F, Dumonteil N, Harmancey R, Hennig S, Perez L, Pathak A, Galinier M, Massabuau P, Malet-Martino M, Senard JM, Rouet P.
    NMR and cDNA array analysis prior to heart failure reveals an increase of unsaturated lipids, a glutamine/glutamate ratio decrease and a specific transcriptome adaptation in obese rat heart.
    J Mol Cell Cardiol. 2007 Mar; 42(3):526-39.
  • Dubroca C, Loyer X, Retailleau K, Loirand G, Pacaud P, Feron O, Balligand JL,
    Lévy BI, Heymes C, Henrion D.
    RhoA activation and interaction with Caveolin-1 are critical for pressure-induced myogenic tone in rat mesenteric resistance arteries.
    Cardiovasc Res. 2007 Jan 1;73(1):190-7.
  • Berthonneche C, Sulpice T, Tanguy S, O’Connor S, Herbert JM, Janiak P, de
    Leiris J, Boucher F.
    AT1 receptor blockade prevents cardiac dysfunction after myocardial infarction in rats.
    Cardiovasc Drugs Ther. 2005 Aug;19(4):251-9.
  • Harmancey R, Senard JM, Pathak A, Desmoulin F, Claparols C, Rouet P, Smih F.
    The vasoactive peptide adrenomedullin is secreted by adipocytes and inhibits lipolysis through NO-mediated beta-adrenergic agonist oxidation.
    FASEB J. 2005 Jun; 19(8):1045-7.
  • Dubroca C, You D, Lévy BI, Loufrani L, Henrion D.
    Involvement of RhoA/Rho kinase pathway in myogenic tone in the rabbit facial vein.
    Hypertension. 2005 May;45(5):974-9.
  • Pathak A, Smih F, Galinier M, Verwaerde P, Rouet P, Philip-Couderc P, Montastruc JL, Senard JM.
    Insulin downregulates M(2)-muscarinic receptors in adult rat atrial cardiomyocytes: a link between obesity and cardiovascular complications.
    Int J Obes (Lond). 2005 Feb; 29(2):176-82.
  • Dubroca C, Lacombe P, Domenga V, Maciazek J, Levy B, Tournier-Lasserve E,
    Joutel A, Henrion D.
    Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy.
    Stroke. 2005 Jan;36(1):113-7.
  • Philip-Couderc P, Smih F, Hall JE, Pathak A, Roncalli J, Harmancey R, Massabuau P, Galinier M, Verwaerde P, Senard JM, Rouet P.
    Kinetic analysis of cardiac transcriptome regulation during chronic high-fat diet in dogs.
    Physiol Genomics. 2004 Sep 16; 19(1):32-40.
  • Berthonneche C, Sulpice T, Boucher F, Gouraud L, de Leiris J, O’Connor SE,
    Herbert JM, Janiak P.
    New insights into the pathological role of TNF-alpha in early cardiac dysfunction and subsequent heart failure after infarction in rats.
    Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H340-50.
  • Loufrani L, Dubroca C, You D, Li Z, Levy B, Paulin D, Henrion D.
    Absence of dystrophin in mice reduces NO-dependent vascular function and vascular density: total recovery after a treatment with the aminoglycoside gentamicin.
    Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):671-6.
  • Buys S, Smih F, Pathak A, Philip-Couderc P, Verwaerde P, Montastruc JL, Rouet P, Senard JM.
    Adrenomedullin upregulates M2-muscarinic receptors in cardiomyocytes from P19 cell line.
    Br J Pharmacol. 2003 Jul;139(6):1219-27.
  • Pelat M, Verwaerde P, Galitzky J, Lafontan M, Berlan M, Senard JM, Montastruc JL.
    High isoproterenol doses are required to activate beta3-adrenoceptor-mediated functions in dogs.
    J Pharmacol Exp Ther. 2003 Jan; 304(1):246-53.
  • Philip-Couderc P, Smih F, Pelat M, Vidal C, Verwaerde P, Pathak A, Buys S, Galinier M, Senard JM, Rouet P.
    Cardiac transcriptome analysis in obesity-related hypertension.
    Hypertension. 2003 Mar; 41(3):414-21.
  • Leducq N, Bono F, Sulpice T, Vin V, Janiak P, Fur GL, O’Connor SE, Herbert JM.
    Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and
    cardiac damage induced by oxidative stress and ischemia-reperfusion.

    J Pharmacol Exp Ther. 2003 Sep;306(3):828-37.
  • Pelat M, Verwaerde P, Tran MA, Montastruc JL, Senard JM.
    Alpha2 –adrenoceptor function in arterial hypertension associated with obesity in dogs fed a high-fat diet.
    J Hypertens. 2002 May; 20(5):957-64.
  • Lazartigues E, Brefel-Courbon C, Bagheri H, Costes S, Gharib C, Tran MA, Senard JM, Montastruc JL.
    Fluoxetine-induced pressor response in freely moving rats: a role for vasopressin and sympathetic tone.
    Fundam Clin Pharmacol. 2000 Sep-Oct; 14(5):443-51.

Clinical research

  • Despas F, Lambert E, Vaccaro A, Labrunee M, Franchitto N, Lebrin M, Galinier
    M, Senard JM, Lambert G, Esler M, Pathak A.
    Peripheral chemoreflex activation contributes to sympathetic baroreflex impairment in chronic heart failure.
    J Hypertens. 2012 Apr;30(4):753-60.

  • Perrin-Terrin A, Pathak A, Lapeyre-Mestre M.
    QT interval prolongation: prevalence, risk factors and pharmacovigilance data among methadone-treated patients in France.
    Fundam Clin Pharmacol. 2011 Aug; 25(4):503-10.

  • Pavy-Le Traon A, Fontaine S, Tap G, Guidolin B, Senard JM, Hanaire H.
    Cardiovascular autonomic neuropathy and other complications in type 1 diabetes.
    Clin Auton Res. 2010 Jun; 20(3):153-60.
  • Franchitto N, Despas F, Labrunée M, Roncalli J, Boveda S, Galinier M, Senard JM, Pathak A.
    Tonic chemoreflex activation contributes to increased sympathetic nerve activity in heart failure-related anemia.
    Hypertension. 2010 Apr; 55(4):1012-7.
  • Tavassoli N, Voisin S, Carrie D, Lapeyre-Mestre M, Galinier M, Montastruc JL, Pathak A.
    High maintenance dosage of clopidogrel is associated with a reduced risk of stent thrombosis in clopidogrel-resistant patients.
    Am J Cardiovasc Drugs. 2010; 10(1):29-35.
  • Despas F, Trouillet C, Franchitto N, Labrunee M, Galinier M, Senard JM, Pathak A.
    Levosimedan improves hemodynamics functions without sympathetic activation in severe heart failure patients: direct evidence from sympathetic neural recording.
    Acute Card Care. 2010 Mar; 12(1):25-30.
  • Despas F, Detis N, Dumonteil N, Labrunee M, Bellon B, Franchitto N, Galinier M, Senard JM, Pathak A.
    Excessive sympathetic activation in heart failure with chronic renal failure: role of chemoreflex activation.
    J Hypertens. 2009 Sep; 27(9):1849-54.
  • Ciarka A, van de Borne P, Pathak A.
    Myocardial infarction, heart failure and sympathetic nervous system activity: new pharmacological approaches that affect neurohumoral activation.
    Expert Opin Investig Drugs. 2008 Sep; 17(9):1315-30.
  • Xhaët O, Argacha JF, Pathak A, Gujic M, Houssiere A, Najem B, Degaute JP, Van de Borne P.
    Sympathoexcitation increases the QT/RR slope in healthy men: differential effects of hypoxia, dobutamine, and phenylephrine.
    J Cardiovasc Electrophysiol. 2008 Feb; 19(2):178-84.
  • Gujic M, Dreyfuss C, Argacha JF, Beloka S, Adamopoulos D, Xhaët O, Pathak A, Van de Borne P.
    Effects of enoximone on peripheral and central chemoreflex responses in humans.
    Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H322-9.
  • Pathak A, Hanon O, Negre-Pages L, Sevenier F; OSCAR investigators.
    Rationale, design and methods of the OSCAR study: observational study on cognitive function and systolic blood pressure reduction in hypertensive patients.
    Fundam Clin Pharmacol. 2007 Apr; 21(2):199-205.
  • Crassous PA, Denis C, Paris H, Sénard JM.
    Interest of alpha2-adrenergic agonists and antagonists in clinical practice: background, facts and perspectives.
    Curr Top Med Chem. 2007; 7(2):187-94.
  • Pavy-Le Traon A, Hughson RL, Thalamas C, Galitsky M, Fabre N, Rascol O, Senard JM.
    Cerebral autoregulation is preserved in multiple system atrophy: A transcranial Doppler study.
    Mov Disord. 2006 Dec; 21(12):2122-6.
  • Lamant M, Smih F, Harmancey R, Philip-Couderc P, Pathak A, Roncalli J, Galinier M, Collet X, Massabuau P, Senard JM, Rouet P.
    ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart.
    J Biol Chem. 2006 Nov 24; 281(47):36289-302.
  • Pathak A, Velez-Roa S, Xhaët O, Najem B, van de Borne P.
    Dose-dependent effect of dobutamine on chemoreflex activity in healthy volunteers.
    Br J Clin Pharmacol. 2006 Sep; 62(3):272-9.
  • Pathak A, Senard JM.
    Blood pressure disorders during Parkinson’s disease: epidemiology, pathophysiology and management.
    Expert Rev Neurother. 2006 Aug; 6(8):1173-80.
  • Pathak A, Raoul V, Montastruc JL, Senard JM.
    Adverse drug reactions related to drugs used in orthostatic hypotension: a prospective and systematic pharmacovigilance study in France.
    Eur J Clin Pharmacol. 2005 Jul; 61(5-6):471-4.
  • Pathak A, Lapeyre-Mestre M, Montastruc JL, Senard JM.
    Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure.
    Mov Disord. 2005 Sep; 20(9):1213-9.
  • Pathak A, Curnier D, Fourcade J, Roncalli J, Stein PK, Hermant P, Bousquet M, Massabuau P, Sénard JM, Montastruc JL, Galinier M.
    QT dynamicity: a prognostic factor for sudden cardiac death in chronic heart failure.
    Eur J Heart Fail. 2005 Mar 2; 7(2):269-75.
  • Philip-Couderc P, Pathak A, Smih F, Dambrin C, Harmancey R, Buys S, Galinier M, Massabuau P, Roncalli J, Senard JM, Rouet P.
    Uncomplicated human obesity is associated with a specific cardiac transcriptome: involvement of the Wnt pathway.
    FASEB J. 2004 Oct; 18(13):1539-40.
  • Pathak A, Senard JM.
    Pharmacology of orthostatic hypotension in Parkinson’s disease: from pathophysiology to management.
    Expert Rev Cardiovasc Ther. 2004 May; 2(3):393-403.
  • Senard JM, Simonetta-Moreau M, Tran MA.
    Blood pressure and heart rate variability in patients with essential hyperhidrosis.
    Clin Auton Res. 2003 Aug; 13(4):281-5.
  • Courbon F, Brefel-Courbon C, Thalamas C, Alibelli MJ, Berry I, Montastruc JL, Rascol O, Senard JM.
    Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson’s disease.
    Mov Disord. 2003 Aug; 18(8):890-7.
  • Berlan M, Verhaeghe S, Pavy-Le Traon A, Thalamas C, Lafontan M, Marques MA, Senard JM, Parent M, Galitzky J.
    Yohimbine administration prevents over-responsiveness to epinephrine induced by simulated microgravity.
    Aviat Space Environ Med. 2002 Aug; 73(8):735-42
  • Mathias CJ, Senard JM, Braune S, Watson L, Aragishi A, Keeling JE, Taylor MD.
    L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failure.
    Clin Auton Res. 2001 Aug; 11(4):235-42.
  • Senard JM, Brefel-Courbon C, Rascol O, Montastruc JL.
    Orthostatic hypotension in patients with Parkinson’s disease: pathophysiology and management.
    Drugs Aging. 2001; 18(7):495-505.
  • Boveda S, Galinier M, Pathak A, Fourcade J, Dongay B, Benchendikh D, Massabuau P, Fauvel JM, Senard JM, Bounhoure JP.
    Prognostic value of heart rate variability in time domain analysis in congestive heart failure.
    J Interv Card Electrophysiol. 2001 Jun; 5(2):181-7.
  • Galinier M, Pathak A, Fourcade J, Androdias C, Curnier D, Varnous S, Boveda S, Massabuau P, Fauvel M, Senard JM, Bounhoure JP.
    Depressed low frequency power of heart rate variability as an independent predictor of sudden death in chronic heart failure.
    Eur Heart J. 2000 Mar; 21(6):475-82.
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